Glycerin 21 vs. Glycerin 22: What’s new?

The Brooks Glycerin series is where luxurious comfort and performance converge. In this article, we will explore into the evolution of the Glycerin series, specifically the Glycerin 21 vs. the new Glycerin 22.
Whether you're an avid runner or just beginning your fitness journey, it’s helpful to understand the key differences in the newest Glycerin 22 to make the best choice for your needs.

The Glycerin series
The Brooks Glycerin family is celebrated for its outstanding cushioning and comfort, making it a preferred choice for runners and walkers at all levels. Whether you're an experienced athlete or a novice who prefers walking, the Glycerin series offers a premium cushion experience with our smartest technology.
A standout feature of the Glycerin series is the combination of soft and responsive nitrogen-infused cushioning into one perfectly and seamlessly tuned experience. It’s an opportunity to experience running with endless energy, making you feel like you could run forever.
Whether you’re exploring the latest Glycerin 22 or sticking with the Glycerin 21, you have the option for our classic fit or extra structured support in our GTS (go-to-support) running shoes. We’ve also introduced the Glycerin Max with a high stack of our DNA Tuned foam and a GlideRoll Rocker for effortless heel-to-tie transitions. With a range of options, you can easily find the perfect Glycerin based on what you’re looking for, and if you’re still not sure, explore our Shoe Finder.
Experience the unmatched comfort and performance of the Glycerin series and elevate your running to new heights. Whether you're running on pavement or out for a long walk, these shoes will support you every step of the way.

Glycerin 21 vs. Glycerin 22: How they compare
Choosing the right running shoe means paying attention to every detail. The Glycerin 22 is an evolution of our popular Glycerin 21, with some exciting new enhancements for those looking for the latest and greatest. Here’s a few key features across both and how they compare:
- Tuned cushioning: While both the Glycerin 21 and Glycerin 22 offer the same midsole drop and height, the Glycerin 22 includes DNA Tuned cushioning, the next generation of nitrogen-infused foam with dual-size cell technology which offers softs landings and powerful toe-offs.
- Improved upper: The Glycerin 22 has an enhanced double jacquard air mesh upper for extra comfort and breathability, and an accommodating and flexible fit.
- Custom fit: Across both the Glycerin 21 and Glycerin 22 there is the opportunity to explore a classic fit or added support with our go-to-support (GTS) via our GuideRails™ technology.
- Smooth transitions: A broad platform helps to stabilize your foot for smooth heel-to-transitions across both the Glycerin 21 and Glycerin 22.

Glycerin 21
The Brooks Glycerin 21 is designed for those seeking maximum comfort and support. With its exceptional design, this shoe is perfect for both seasoned runners and beginners.
One of the standout features of the Glycerin 21 is its plush cushioning. Equipped with Brooks' DNA LOFT v3 technology, this shoe provides an incredibly soft and luxurious feel with every step. It was also the first shoe in the Glycerin series to include RoadTack rubber. The Glycerin 21 might be your perfect fit, but if you’re curious about our latest innovation, the Glycerin 22 is here.

Glycerin 22
The Glycerin 22 is the latest in the Glycerin series and is a premium running shoe designed to provide luxurious comfort with airy landings and electric toe-offs.
You will find DNA Tuned in the Glycerin 22, our new nitrogen-infused foam that seamlessly blends dual-sized cells optimized for plush landings and responsive toe-offs. The Glycerin Max was the first shoe we launched with DNA Tuned! The Glycerin 22 also offers a comfortable, accommodating fit with a newly engineered double jacquard knit upper.
The latest Glycerin 22 is meant to help you unlock that “run forever” feeling, whether it’s in the classic fit or GTS if you need a bit of extra support.
Is it time to upgrade to the Glycerin 22?
Both the Glycerin 21 and Glycerin 22 are a great option if you’re a runner, or even if you’re an avid walker looking for support and cushioning.
The Glycerin 21 has our DNA LOFT v3 midsole and the warp knit upper, while the Glycerin 22 has been updated to include the latest DNA Tuned midsole combined with an enhanced double jacquard air mesh upper for extra comfort and breathability.
Finding the right fit is truly based on your personal preferences. Whether it’s the latest Glycerin 22 or you’re looking to explore some of our other popular running shoes like the Adrenaline GTS or Ghost, we’ve got you covered.
Still need help making a decision? Consider popping into your local running store for some support.
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Disclaimer: Our writer's advice is intended for informational or general educational purposes only. We always encourage you to speak with your physician or healthcare provider before making any adjustments to your running, nutrition, or fitness routines.